Jun 17, 2004 12:22
19 yrs ago
English term
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Native in: Chinese 
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Bifonazole
English
Tech/Engineering
Chemistry; Chem Sci/Eng
Hi chemist here, can somebody tell me about the nomenclature of this chemical Bifonazole?
I have found its name Bifonazole and the chemical name 1-[(1,1'-Biphenyl)-4-ylphenylmethyl]-1H-imidazole£¬and 1-(p,¦Á-Diphenylbenzyl)imidazole as well as its cas No. 60628-96-8 at a Japanese website http://www.chemlaw.co.jp/Result_Eng_B/Bifonazole.htm and I found its structure at a Chinese website http://www.aikechem.com/new-pro-gb-yly-6.htm. Can somebody answer me in simple English about the following question?
In ¡°chemical name No. 1(1-[(1,1'-Biphenyl)-4-ylphenylmethyl]-1H-imidazole), why there is a 1H, what does it mean, and what does -4-ylphenylmethyl and 1,1'-Biphenyl mean£¿
In ¡°chemical name No. 2(1-(p,¦Á-Diphenylbenzyl)imidazole), what does p,¦Á mean? Hard job, isn¡¯t! Thanks in advance!
I have found its name Bifonazole and the chemical name 1-[(1,1'-Biphenyl)-4-ylphenylmethyl]-1H-imidazole£¬and 1-(p,¦Á-Diphenylbenzyl)imidazole as well as its cas No. 60628-96-8 at a Japanese website http://www.chemlaw.co.jp/Result_Eng_B/Bifonazole.htm and I found its structure at a Chinese website http://www.aikechem.com/new-pro-gb-yly-6.htm. Can somebody answer me in simple English about the following question?
In ¡°chemical name No. 1(1-[(1,1'-Biphenyl)-4-ylphenylmethyl]-1H-imidazole), why there is a 1H, what does it mean, and what does -4-ylphenylmethyl and 1,1'-Biphenyl mean£¿
In ¡°chemical name No. 2(1-(p,¦Á-Diphenylbenzyl)imidazole), what does p,¦Á mean? Hard job, isn¡¯t! Thanks in advance!
Responses
| 5 | FYI |
ysun
|
| 4 +3 | antifungal medicine known as an imidazole |
Ray Luo
|
Responses
121 days
Selected
FYI
Jianming,
I accidentally saw this question in the English-English pair. The following is my opinion:
In ¡°chemical name No. 1: (1-[(1,1'-Biphenyl)-4-yl phenylmethyl]-1H-imidazole),
1H is called ¡°indicated Hydrogen¡±, which indicates that the hydrogen which is replaced by the big substituting group was at the 1-position of imidazole. In this case, it can be omitted.
(1,1'-Biphenyl)-4-yl means 1,1'-Biphenyl has lost one hydrogen at the 4-position to become a substituting group. Phenylmethyl = benzyl
1,1'-Biphenyl indicates that the numbering starts with the two carbon atoms which connect the two benzene rings with each other. Otherwise, -4-yl would make no sense since you don't know what the No. 1 is. Here, 1 refers to the position on one ring, while 1'- refers to the position on the other.
In ¡°chemical name No. 2: (1-(p,¦Á-Diphenylbenzyl)imidazole),
I think p,¦Á-Diphenyl is simply an error. It should be ¦Á,¦Á-Diphenyl, which has the same meaning as 1,1'-Biphenyl. In some chemicals, ¦Á means 1 and ¦Â means 2, and so on.
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Note added at 122 days (2004-10-17 14:55:49 GMT)
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To answer your added note, the methyl group is directly connected to the imidazole. Both (1,1\'-Biphenyl)-4-yl and phenyl are connected to the methyl group. If you take the (1,1\'-Biphenyl)-4-yl and phenyl groups away, what remains will be 1-methyl-1H-imidazole.
I accidentally saw this question in the English-English pair. The following is my opinion:
In ¡°chemical name No. 1: (1-[(1,1'-Biphenyl)-4-yl phenylmethyl]-1H-imidazole),
1H is called ¡°indicated Hydrogen¡±, which indicates that the hydrogen which is replaced by the big substituting group was at the 1-position of imidazole. In this case, it can be omitted.
(1,1'-Biphenyl)-4-yl means 1,1'-Biphenyl has lost one hydrogen at the 4-position to become a substituting group. Phenylmethyl = benzyl
1,1'-Biphenyl indicates that the numbering starts with the two carbon atoms which connect the two benzene rings with each other. Otherwise, -4-yl would make no sense since you don't know what the No. 1 is. Here, 1 refers to the position on one ring, while 1'- refers to the position on the other.
In ¡°chemical name No. 2: (1-(p,¦Á-Diphenylbenzyl)imidazole),
I think p,¦Á-Diphenyl is simply an error. It should be ¦Á,¦Á-Diphenyl, which has the same meaning as 1,1'-Biphenyl. In some chemicals, ¦Á means 1 and ¦Â means 2, and so on.
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Note added at 122 days (2004-10-17 14:55:49 GMT)
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To answer your added note, the methyl group is directly connected to the imidazole. Both (1,1\'-Biphenyl)-4-yl and phenyl are connected to the methyl group. If you take the (1,1\'-Biphenyl)-4-yl and phenyl groups away, what remains will be 1-methyl-1H-imidazole.
4 KudoZ points awarded for this answer.
Comment: "Hi Yueyin! Thank you so much! Obviously my head is not clear yesterday evening! I was really tired by German learning in the weekend. Language learning is truly a hard endeavor. What I meant by "position 4" is really position 1 in 1, 1'-biphenyl. I must keep trying to get familiarized with chemical nomenclature. Such expression as ¡°4-yl¡± is a little difficult for us to understand. Now I know it means that in position 4 of (1, 1'-biphenyl) group, a phenylmethyl group is connected. "
+3
43 mins
antifungal medicine known as an imidazole
Declined
How does it work?
This medicine contains the active ingredient bifonazole, which is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.
Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear.
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.
Bifonazole cream is used to treat the fungal skin infection athlete's foot (tinea pedis). You should wash and dry the feet, especially between the toes, before applying the medicine.
What is it used for?
This medicine contains the active ingredient bifonazole, which is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.
Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear.
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.
Bifonazole cream is used to treat the fungal skin infection athlete's foot (tinea pedis). You should wash and dry the feet, especially between the toes, before applying the medicine.
What is it used for?
Peer comment(s):
| agree |
Vicky Papaprodromou
28 mins
|
| agree |
Alfa Trans (X)
6 hrs
|
| neutral |
Craft.Content
: Ray, the asker wants input on the chemical formulae.
11 hrs
|
| agree |
Rajan Chopra
17 days
|
Comment: "I said what I want to know is about the nomenclature "
Discussion
http://www.aikechem.com/new-pro-gb-yly-6.htm
Thank you so much!
I am going to bed. See you later.
The 1H, -4-ylphenylmethyl, and 1,1-Biphenyl describe the chemical composition of the substance. Ditto for p,|A. These are all chemical formulae.