Glossary entry (derived from question below)
English term or phrase:
metabolic liability
English answer:
metabolic instability
Added to glossary by
ysun
Dec 7, 2007 18:30
16 yrs ago
4 viewers *
English term
metabolic liability
English
Medical
Medical (general)
Context:
Given the wide distribution of SSAO (semicarbazide-sensitive amine oxidase) in many bodily compartments, we believe SSAO may be an important enzyme that contributes to a drug's potential metabolic liability.
I would appreciate it if you could explain what metabolic liability means. Thank you in advance!
Given the wide distribution of SSAO (semicarbazide-sensitive amine oxidase) in many bodily compartments, we believe SSAO may be an important enzyme that contributes to a drug's potential metabolic liability.
I would appreciate it if you could explain what metabolic liability means. Thank you in advance!
Responses
+2
1 hr
Selected
Explanation below.
I think metabolic liability has a nice ring to it. There is no need to change the term, only to understand its meaning.
Apparently the drug in question has an effect on the enzyme SSAO.
The text states that SSAO is found in many "bodily compartments", which means that it is found in several organs or organ systems. Thus a modification of the performance of this enzyme is likely to have more than one effect on the function of the body as the enzyme may have different effects depending on which "compartment" it is found. The "metabolic liability" refers to the potential for side effects of this medication due to the fact that a modification of the enzyme's function may be beneficial in one compartment but disadvantageous in another.
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Note added at 4 hrs (2007-12-07 22:32:33 GMT)
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Generalizing, because of the enzyme's widespread distribution in the body, any medication that affects it has a high potential for side effects.
There is no intent to refer to the way the drug is metabolized. The term "biochemical" could be substituted for "metabolic" in this context, with no change in meaning.
Apparently the drug in question has an effect on the enzyme SSAO.
The text states that SSAO is found in many "bodily compartments", which means that it is found in several organs or organ systems. Thus a modification of the performance of this enzyme is likely to have more than one effect on the function of the body as the enzyme may have different effects depending on which "compartment" it is found. The "metabolic liability" refers to the potential for side effects of this medication due to the fact that a modification of the enzyme's function may be beneficial in one compartment but disadvantageous in another.
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Note added at 4 hrs (2007-12-07 22:32:33 GMT)
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Generalizing, because of the enzyme's widespread distribution in the body, any medication that affects it has a high potential for side effects.
There is no intent to refer to the way the drug is metabolized. The term "biochemical" could be substituted for "metabolic" in this context, with no change in meaning.
4 KudoZ points awarded for this answer.
Comment: "Thank you, Michael! Thank you, everybody!"
+1
19 mins
a disadvantage in the way the drug is metabolized
Drugs with metabolic liability are readily metabolized and secreted, thereby leading to poor bioavailability and high clearance, while formation of active or toxic metabolites may also impact pharmacological outcomes.
1 hr
hinders the human metabolic chemistry
liability = hindrance/disadvantage
Drug Discovery Today : Improving the decision-making process in ...
High clearance rates, high metabolic liability (usually leads to poor bioavailability) and the formation of active or toxic metabolites (has an impact on ...
linkinghub.elsevier.com/retrieve/pii/S1359644604032805 - Similar pages
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PPT]
Pres
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High metabolic liability usually leads to poor bioavailability and high clearance, and formation of active or toxic metabolites will have an impact on the ...
web.uconn.edu/rusling/Nassar.ppt - Similar pages
so if a drug is a metabolic liability, perhaps this means that this drug will hinder the human metabolic chemistry..
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Note added at 1 hr (2007-12-07 19:37:55 GMT)
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i.e is not absorbed properly by the human body
Drug Discovery Today : Improving the decision-making process in ...
High clearance rates, high metabolic liability (usually leads to poor bioavailability) and the formation of active or toxic metabolites (has an impact on ...
linkinghub.elsevier.com/retrieve/pii/S1359644604032805 - Similar pages
[ More results from linkinghub.elsevier.com ]
PPT]
Pres
File Format: Microsoft Powerpoint - View as HTML
High metabolic liability usually leads to poor bioavailability and high clearance, and formation of active or toxic metabolites will have an impact on the ...
web.uconn.edu/rusling/Nassar.ppt - Similar pages
so if a drug is a metabolic liability, perhaps this means that this drug will hinder the human metabolic chemistry..
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Note added at 1 hr (2007-12-07 19:37:55 GMT)
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i.e is not absorbed properly by the human body
37 mins
metabolic risk
SSAO is an independent prognostic marker for mortality in chronic heart failure and patients with diabetes. It is involved in vascualr endothelial damage through the formation of reactive aldehydes, H202 & ammonia from endogenous substrates. Drugs with similar chemical structures to endogenous substrates may increase this risk (liability) of metabolic damage.
I would however keep the same term--metaboloc
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Note added at 2 days24 mins (2007-12-09 18:55:08 GMT)
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There is a typo last sentence reads:
I would however keep the same term: metabolic liability
I would however keep the same term--metaboloc
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Note added at 2 days24 mins (2007-12-09 18:55:08 GMT)
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There is a typo last sentence reads:
I would however keep the same term: metabolic liability
Example sentence:
the drug's risk for producing metabolic vascular damage
Peer comment(s):
| neutral |
Michael Barnett
: This is a very interesting interpretation but I would think that a drug would have to be given in massive amounts if it were to act as a substrate. Drugs work in tiny doses by modifying enzyme systems. I agree though with "metabolic risk".
11 hrs
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This is not what I mean. The chemical structure of a drug may be similar to endogenous substrates with which SSAO interact and conequently lead to the production of products that increase metabolic damage.
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Discussion
A non-limiting example of one embodiment of the instant invention is to investigate whether a particular test agent or compound has greater risk for metabolic liability or conversely is metabolically stable in one tissue compartment versus other tissue compartments, e.g., whether a compound has greater metabolic stability in liver compared to lung.