Glossary entry (derived from question below)
English term or phrase:
Curve peeling techniques
French translation:
technique d\'approximation de la courbe cinétique (curve peeling)
English term
Canada
Canadian French, Certified Translator
Native in: English 
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Curve peeling techniques
| 4 +2 | technique d'approximation de la courbe cinétique (curve peeling) |
FX Fraipont (X)
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Apr 29, 2013 15:20: FX Fraipont (X) changed "Level" from "Non-PRO" to "PRO"
PRO (3): Marion Feildel (X), Tristan Jimenez, FX Fraipont (X)
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Proposed translations
technique d'approximation de la courbe cinétique (curve peeling)
L’HOMME - THÉSE DE DOCTORAT
Spécialité : Pharmacologie Expérimentale et Clinique
ÉCOLE DOCTORALE : Biologie-Santé
Présentée et soutenue publiquement le : 27 janvier 2009
à : la faculté de médecine- Université d’Angers
Méthode " d’épluchage, de pelage " (peeling) : Il s’agit d’une méthode dont l’application est limitée aux modèles exprimés en somme
d’exponentielles. Elle ne converge pas quand les constantes sont approximativement égales.
De plus, elle est considérée comme peu efficiente compte tenu de l’utilisation partielle des
données pour estimer chaque paramètre. Néanmoins, cet " épluchage " de la courbe cinétique est souvent programmé dans les logiciels, pour estimer les valeurs initiales des paramètres."
Modélisation appliquée à la pharmacocinétique de molécules ...
http://tel.archives-ouvertes.fr/.../These_C.Abbara_Jan_2009.... this page
by C Abbara - 200
"What is curve stripping?
July 6, 2011 By Nathan Teuscher Leave a Comment
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic profile is made up of one or more exponential phases. The “curve stripping” process extracts each of these exponential phases from the pharmacokinetic profile in a manual fashion that does not require non-linear curve fitting. This method was originally used to estimate pharmacokinetic parameters prior to computers. It is now used to estimate initial parameter estimates for some non-linear curve fitting programs.
To execute a curve stripping procedure, you will need a graph of the data along with a “spreadsheet” of the concentration-time data. Starting at the terminal phase of the curve (final time points with measurable concentrations), a best-fit line is drawn to the log-transformed concentration-time data. An example of this is shown in the following figure with the blue circles representing the concentration-time data and the red line the best-fit line"
http://learnpkpd.com/2011/07/06/what-is-curve-stripping/
"Description de l’enseignement Notions de linéarité en pharmacocinétique. Ecriture et résolution des systèmes d’équations différentielles pour les modèles à 1 et plusieurs compartiments avec différentes voies d’administration (IV, EV, perf.). Calculs et interprétation des principaux paramètres pharmacocinétique : clairance, biodisponiblilité, volume de distribution, temps de demie vie. Interprétation stochastique des modèles de cinétiques linéaires : analyse non compartimentale. Méthodes d’estimation des paramètres : méthodes approchées (peeling), introduction à la régression non linéaire. Présentation des principaux modèles PK/PD : modèles directs et indirects."
http://www.biostat.envt.fr/master/spip.php?article52
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