English to Italian Medical Genetics Ricerca sulle cellule staminali embrionali

Progetto di ricerca sull'atlante del genoma:

Beyond the complete sequence of the mammalian genome lies the blueprint for the complete development and subsequent regulation throughout the life of the animal. Genetic information is used in subsets of stem cells that define many potential avenues of development and expression. A major European initiative in genomic research aimed to map these subsets in pluripotent, selected differentiated cell types to make an atlas of mammalian genome use in early development. (...) The researchers successfully elucidated how ES (embryo stem) cells renew themselves, and 'select' a developmental pathway to different organ-specific cells, so-called lineage commitment. Potential novel target genes have been identified for therapeutic intervention.The next step was to establish screening procedures of small candidate molecules to target the genes in the **developmental cascades**.

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Federica